|
KMID : 0191119980130050500
|
|
Journal of Korean Medical Science
1998 Volume.13 No. 5 p.500 ~ p.506
|
|
|
Clinical response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn
|
|
Ko SY
Chang YS/Park WS
|
|
|
Abstract
|
|
|
We observed clinical response to inhaled nitric oxide (iNO) in 12 neonates with persistent pulmonary
hypertension of the newborn (PPHN). Clinical response was defined as a decrease in oxygenation index
(OI) by 40%. Ten of 12 neonates had response to iNO showing decrease OI from 46.1+/-7.6 to 14.4+/-6.8 at
1 hour after inhalation. Sustained improvement of OI was achieved in 8 neonates and two neonates were
relapsed. In the group of neonates who had OI above 40 (n=7), 6 of them showed the decrease of OI from
66.1+/-4.8 to 18.3+/-8.0 at 1 hour. In two groups, one had OI of 40 or greater, and the other OI of 40
or less, there were no differences in pattern of response and early death rate. The response rates
according to underlying diseases were as follows; idiopathic PPHN 100%, respiratory distress syndrome
100%, and diaphragmatic hernia 66.7%. Relapse was observed in one neonate with sepsis caused by pneumonia
and in one infant with meconium aspiration syndrome. Two infants showed no response to iNO (one diaphragmatic
hernia and one suspected pulmonary hypoplasia). We conclude that iNO therapy could improve oxygenation in
high percentage of newborn infants with severe PPHN of various underlying conditions except pulmonary
hypoplasia.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|